Figure 2.

Change in effective connectivity across blocks: The bidirectional connectivity profile that distinguished the three groups: within-group connectivity between the left mPFC and the right amygdala shown across the three successive task blocks, whose enhanced engagement for fronto-limbic modulation was found to differentiate between AN, BDD, and controls. (A) With the mPFC-to-amygdala connectivity, a monotonically increasing trend is apparent, with the change being significantly large (p < 0.05, Bonferroni corrected) in HCs and in BDD, but not in AN. It is also noticeable that the variability monotonically increases from block1 through block3 in all the groups, suggesting increased inter-subject variability in fronto-limbic engagement as the blocks progress. (B) With the amygdala-to-mPFC connectivity, a monotonically increasing trend is apparent only in HCs, with the change being significantly large (p < 0.05, Bonferroni corrected). p-values in the figure correspond to within-group block-to-block comparisons.