Figure 1.

Sub-network with a size cut-off $\beta$ of 28 between D-glucose and L-phenylalanine in S. cerevisiae iMM904. Dark gray rectangles represent reactions, light gray circles represent metabolites. The nomenclature of reaction and metabolite names are consistent with iMM904 genome-scale metabolic model. The source and the target metabolite is glc-D_c and phe-L_c respectively (shown in boldface and italics). We note that the synthesis of L-phenylalanine involves several metabolites from different compartments. The reactions in this pathway and the seed metabolites can be found in Supplementary Results $\mathrm{\S }$ 5.1 and Supplementary Table S3 respectively.