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. 2018 Jun 26;9:709. doi: 10.3389/fphys.2018.00709

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Copyright © 2018 Paci, Pölönen, Cori, Penttinen, Aalto-Setälä, Severi and Hyttinen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustrative experimental Ca²⁺ transients from four cells (blue, cyan, green, magenta) and the Ca²⁺ transient simulated by the Paci2018 model (black). The y-axis of the experimental traces (originally ΔF/F) was normalized between the minimum and maximum values of the simulated trace for comparison. The inset contains only the decay part (from 90 to 10% of the transient amplitude) of the experimental and simulated transients reported in the main Figure.