Figure 7.

Repolarization abnormalities with standard extracellular Ca²⁺ concentrations. Such behavior was obtained with a control extracellular Ca²⁺ concentration Ca_o = 1.8 mM, shifting RyR_o,half and RyR_c,half by −0.002 and 0.002 mM respectively, doubling RyR_o time constant and reducing to half of its nominal value RyR_c time constant. These traces show the ability of the Paci2018 to simulate pathological conditions affecting the Ca²⁺ from SR. (A) Membrane potential. (B) I_NaCa. (C) Cytosolic Ca²⁺ concentration. (D) I_rel. A similar morphology of the cytosolic Ca²⁺ time-course is reported in Kim et al. (2015) in their Figure 4B.