Skip to main content
. 2018 Apr 4;41(6):633–645. doi: 10.1007/s12272-018-1025-3

Table 2.

The activity data of compounds 1934 expressed as MIC (MBC or MFC) [µg/ml] and {MBC/MIC or MFC/MIC} against the reference strains of bacteria and fungi

Species MIC (MBC/MFC) [µg/ml] and {MBC/MIC or MFC/MIC} of the tested compounds MIC (MBC) [µg/ml] of reference substances
CIP/NY* NIT CFX APC PA
19 20 21 34
Gram-positive bacteria
 Staphylococcus aureus ATCC 25923 1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
500
(> 1000)
{nd}
1000
(> 1000)
{nd}
0.488 15.62 0.49 nd 31.25
(62.5)
 Staphylococcus aureus ATCC 6538 1000
(> 1000)
{nd}
500
(> 1000)
{nd}
500
(> 1000)
{nd}
0.244 15.62 0.98 nd 62.5
(125)
 Staphylococcus aureus ATCC 43300 1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
0.244 7.81 nd nd 62.5
(125)
 Staphylococcus epidermidis ATCC 12228 1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
0.122 3.91 0.24 nd 15.62
(62.5)
 Micrococcus luteus ATCC 10240 500
(> 1000)
{nd}
1000
(> 1000)
{nd})
500
(> 1000)
{nd}
500
(> 1000)
{nd}
0.976 62.5 0.98 nd 125
(250)
 Bacillus subtilis ATCC 6633 500
(> 1000)
{nd}
500
(1000)
{2}
1000
(> 1000)
{nd}
0.031 3.91 15.62 nd 3.91
(7.81)
 Bacillus cereus ATCC 10876 1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
500
(> 1000)
{nd}
1000
(> 1000)
{nd}
0.061 7.81 31.25 62.5 15.62
(62.5)
Gram-negative bacteria
 Bordetella bronchiseptica ATCC 4617 1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
0.976 125 nd nd 31.25
(62.5)
 Klebsiella pneumoniae ATCC 13883 0.122 15.62 nd nd 15.62
(31.25)
 Proteus mirabilis ATCC 12453 0.030 62.5 nd nd 1.95
(3.91)
 Salmonella typhimurium ATCC 14028 0.061 31.25 nd nd 1.95
(3.91)
 Escherichia coli ATCC 25922 0.004 7.81 nd nd 0.98
(1.95)
 Pseudomonas aeruginosa ATCC 9027 0.488 nd nd nd 31.25
(62.5)
Fungi
 Candida albicans ATCC 2091 250
(1000)
{4}
250
(1000)
{4}
500
(> 1000)
{nd}
0.24* na na na na
 Candida albicans ATCC 10231 250
(1000)
{4}
250
(1000)
{4}
500
(> 1000)
{nd}
0.48* na na na na
 Candida parapsilosis ATCC 22019 500
(1000)
{2}
500
(1000)
{2}
1000
(> 1000)
{nd}
0.24* na na na na
 Candida glabrata ATCC 90030 500
(> 1000)
{nd}
1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
0.24* na na na na
 Candida krusei ATCC 14243 1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
1000
(> 1000)
{nd}
0.24* na na na na

The standard compounds used as positive controls: ciprofloxacin (CIP), nitrofurantoin (NIT), cefuroxime (CFX), ampicillin (APC) and pipemidic acid (PA) for bacteria and nystatin (NY*) for fungi. Compounds with bactericidal effect (MBC/MIC ≤ 4) are marked in bold. All the experiments were repeated three times (n = 3) and representative data is presented

nd not determined, na not applicable, “–” no activity