Table 1.

Summary of the analysed studies

SNP analysed	Results	Study group	Disease	Age of studied population	Country	Authors
TLR4 rs4986791 TLR4 rs4986790	no association	185 IMD 770 HC	IMD MM	Adults and children	Austria	Biebl et al. [34]
TLR4 rs4986790	no association	1047 IMD 879 BD	IMD	Adults and children	UK	Read et al. [33]
TLR 9 rs352140 TLR 9 rs5743836	TLR9 rs5743836—ProMM p < 0.01	390 MM	MM	Children	Netherlands	Sanders et al. [37]
TLR4 rs4986790	TLR4 rs4986790 - ProIMD p = 0.007 in children younger than 12 months	197 IMD 214 HC	IMD	Adults and children	Germany	Faber et al. [30]
TIRAP rs8177374 NFKBIA rs3138053 NFKBIA rs2233406 NFKBIE rs529948 NFKBIZ rs6165997 TONSL rs760477 PTPN22 rs2476601	NFKBIE rs529948 SuPM p < 0.0001 all SNPs —no association in MM	372 PM 907 PB 1273HC 406 MM 272 HC	PM MM	children	Denmark	Lunbdo et al. [39]
NFKBIL2 rs760477 NFKBIL2 rs2306384 NFKBIL2 rs4082353 NFKBIL2 rs4925858 NFKBIL2 rs10448143 NFKBIL2 rs2170096 NFKBIL2 rs2272658 NFKBIL2 rs135258200 NFKBIL2 rs4380978	NFKBIL2 rs760477 SuIPD p = 0.0006 NFKBIL2 rs4925858 SuIPD p = 0.003 remaining SNPs —no association	UK 275 patients 733 HC Kenya 687 patients 173 PB 550 HC	IPD	Adults Children	UK Kenya	Chapman et al. [40]
TLR2 rs5743708 TLR2 rs5743708 TLR4 rs4986790	TLR4 rs4986790 SuIMD p = 0.0472 TLR 2 rs5743708 SuIMD p = 0.0003 TLR 2 rs5743708 SuIPD p < 0.0001	59 IMD 18 MM 114 IPM 12 PM 66 HC	MM PM	Children	Europe	Telleria-Orriols et al. [31]
TIRAP rs8177374	TIRAP rs8177374 ProIPD p = 0.003	191 IPD 741 HC	IPD	Adults children	UK	Khor and al [25]
TLR2 rs5743708 TLR4 rs4986790 TLR4 rs4986791	no association	99 IPD 178 HC	IPD	–	Belgium	Moens et al. [28]
TLR2 rs5743708 TLR4 rs4986790 TLR4 rs4986791 CD14-159CC FcγRIIA-R/R131	TLR4 rs4986790 ProPM p < 0.005 CD14-159CC SuIPD p < 0.05 FcγRIIA-R/R131 SuIPD p < 0.001 remaining SNPs —no association	85 IPD 409 BD	IPD	Children	Australia	Yuan and al [29]
TLR2 TLR4 total nucleotide variation	TLR2 rs57437708 more common in patients p = 0.05	197 IMD 238 HC	IMD	Children	UK	Smirnova et al. [32]
TLR2 rs5743708 TLR4 rs4986790 NOD1 rs6958571 NOD2 rs5743293 NOD2 rs2066847 NOD2 rs2066844 CASP1 rs2282659	TLR4 rs4986790 SuMM NOD2 rs2066847 SuMM remaining SNPs —no association	391 MM 82 PM 1141 HC	MM PM	Children	Netherlands	Van Wel et al. [36]
TLR4 rs4986790 TLR4 rs4986791	no association	252 MM 251 HC	MM	Children	Gambia	Allen et al. [35]
TLR2 rs3804099 TLR3 rs3775291 TLR3 rs3775290 TLR9 rs352139 TLR9 rs352140	no association	218 MB 330 HC	BM	Children	China	Zhang et al. [38]

Bold values indicate significant results

BD blood donors, BM bacterial meningitis, HC healthy controls, IPD invasive pneumococcal disease, IMD invasive meningococcal disease, MM meningococcal meningitis, PM pneumoccoccal meningitis, PB pneumoccoccal bacteraemia, SuPM susceptibility to pneumococcal meningitis, SuIPD susceptibility to invasive pneumococcal disease, SuIMD susceptibility to invasive meningococcal disease, SuMM susceptibility to meningococcal meningitis, ProIMD protection against invasive meningococcal disease, ProPM protection against pneumococcal meningitis