Table 2.
Univariate associations of patient and lesion characteristics with false negatives on DBT
| Patient characteristics | True positive | False negative | Significancea | |||
|---|---|---|---|---|---|---|
| R1 | R2 | R1 | R2 | R1 | R2 | |
| Age | OR = 1.02 95% CI = 0.98-1.05 | OR = 1.01 95% CI = 0.98-1.05 | p = 0.334 | p = 0.503 | ||
| Breast composition | p = 0.155 | p = 0.649 | ||||
| a (fatty) | 3 (2) | 4 (3) | 0 (0) | 0 (0) | ||
| b | 19 (14) | 26 (19) | 0 (0) | 2 (11) | ||
| c | 93 (71) | 86 (64) | 15 (75) | 12 (67) | ||
| d (dense) | 17 (13) | 18 (13) | 5 (25) | 4 (22) | ||
| Breast composition | p = 0.080 | p = 0.366 | ||||
| a + b (fatty) | 22 (17) | 30 (22) | 0 (0) | 2 (11) | ||
| c + d (dense) | 110 (83) | 104 (78) | 20 (100) | 16 (89) | ||
| FGT | p = 0.698 | p = 0.763 | ||||
| a (fatty) | 9 (7) | 9 (7) | 0 (0) | 0 (0) | ||
| b | 41 (31) | 39 (29) | 5 (25) | 7 (39) | ||
| c | 68 (52) | 72 (54) | 13 (65) | 9 (50) | ||
| d (extreme) | 14 (11) | 14 (10) | 2 (10) | 2 (11) | ||
| BPE | p = 0.558 | p = 0.394 | ||||
| Minimal | 28 (23) | 28 (23) | 3 (17) | 3 (19) | ||
| Mild | 37 (30) | 39 (32) | 8 (44) | 6 (38) | ||
| Moderate | 34 (28) | 35 (28) | 3 (17) | 2 (13) | ||
| Marked | 23 (19) | 22 (18) | 4 (22) | 5 (31) | ||
| PD | OR = 1.02 95% CI = 0.99-1.05 | OR = 1.01 95% CI = 0.98-1.04 | p = 0.277 | p = 0.553 | ||
| Breast thickness | OR = 0.98 95% CI = 0.94-1.01 | OR = 0.98 95% CI = 0.94-1.02 | p = 0.205 | p = 0.237 | ||
| Lesion characteristics | True positive | False negative | ||||
| Size | OR = 0.95 95% CI = 0.90-1.02 | OR = 0.93 95% CI = 0.87-1.00 | p = 0.115 | p = 0.041 | ||
| Type of finding | p = 0.266 | p = 1.000 | ||||
| Invasive | 64 (77) | 63 (74) | 13 (65) | 14 (78) | ||
| In-situ | 19 (23) | 22 (26) | 7 (35) | 4 (22) | ||
| Histological type | p = 0.190 | p = 0.230 | ||||
| Ductal | 55 (86) | 54 (86) | 9 (69) | 10 (71) | ||
| Lobular | 4 (6) | 4 (6) | 2 (15) | 2 (14) | ||
| Other | 5 (8) | 5 (8) | 2 (15) | 2 (14) | ||
| Histological grade | p = 0.810 | p = 0.660 | ||||
| Grade 1 | 21 (33) | 20 (32) | 3 (23) | 4 (29) | ||
| Grade 2 | 24 (38) | 25 (40) | 5 (39) | 4 (29) | ||
| Grade 3 | 19 (30) | 18 (29) | 5 (39) | 6 (43) | ||
| Subtypeb | p = 0.854 | p = 0.601 | ||||
| Luminal a | 36 (56) | 36 (57) | 9 (69) | 9 (64) | ||
| Luminal b HER2- | 13 (20) | 13 (21) | 2 (15) | 2 (14) | ||
| Luminal b HER2+ | 6 (9) | 6 (10) | 0 (0) | 0 (0) | ||
| HER2+ non-luminal | 2 (3) | 2 (3) | 0 (0) | 0 (0) | ||
| Triple negative | 7 (11) | 6 (10) | 2 (15) | 3 (21) | ||
Numbers in parentheses are percentages
R reader, FGT fibroglandular tissue, BPE background parenchymal enhancement, PD percent density, OR odds ratio, CI confidence interval
aLogistic regression and Fisher’s exact test were used for continuous and discrete data, respectively
bSt Gallen 2013 classification