Fig. 8.

Conformations of the selectivity filter carbonyl groups. The orientation of the T63-G67 carbonyl groups with respect to the conduction pathway was explored. The 2D plots show the $(C,C_{\mathit{\alpha }},N,O)$ dihedral and the distance of the carbonyl oxygen to the pore axis. Each point corresponds to a single conformation of ${\text{Kcv}}_{\text{PBCV-1}}$ . The rows represent the T63-G67 residues, and the columns—the four channel subunits. On each plot, the two reference points, corresponding to the structures of the NaK2K (red) and hERG channels (black), are shown