Combination therapy is the standard of care in pulmonary arterial hypertension (PAH); however, there is a need for clear, practical advice for using this approach in the clinic.

Combination therapy must be carefully managed by an experienced, multidisciplinary team, with particular focus on the timing of treatment initiation, management of side effects and maintaining adherence to potentially complex treatment regimens.

Combination therapy can be effectively managed in expert centers and provides long-term benefits for PAH patients.