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Prediction-corrected visual predictive checks of the final model for metformin. Observed concentrations are shown as blue circles with solid, lower and upper dashed red lines showing the median, 2.5th and 97.5th percentiles of the observed data, respectively. The shaded areas represent 95% confidence intervals for the median, 2.5th and 97.5th percentiles of simulated concentrations (n = 1000), based on the original dataset
