Fig. 4.

Oral metformin clearance (population prediction [line] and empirical Bayes estimates [triangles]) from 22 overweight and obese adolescents versus WT_{for age and length} for different WT_excess levels (i.e., 15, 30, and 50 kg, dark grey/black lines). Population values for oral clearance are composed of the clearance of non-obese adolescents (WT_{excess 0 kg}, light grey dotted line) plus an increase related to WT_excess according to Eqs. (5) and (6). Observed individual values of obese adolescents are represented by triangles with grey/black scales varying according to the degree in WT_excess. WT_excess excess body weight, WT_{for age and length} developmental weight