Table 1.

MD simulation types and their abbreviations used in the text

Simulated system	Abbreviation	Average RMSD [Å]	Average RG [Å]
Wild-type ribosome fragment with clindamycin	WT–CLY-1	2.18 ± 0.03	28.88 ± 0.04
	WT–CLY-2	2.16 ± 0.03	28.86 ± 0.04
	WT–CLY-3	2.19 ± 0.03	28.91 ± 0.03
	WT–CLY-4	2.26 ± 0.04	28.88 ± 0.04
A2058G mutated ribosome fragment with clindamycin	MUT–CLY-1	3.01 ± 0.04	29.40 ± 0.04
	MUT–CLY-2	3.05 ± 0.04	29.40 ± 0.03
	MUT–CLY-3	3.02 ± 0.03	29.40 ± 0.03
Wild-type ribosome fragment	WT-1	2.51 ± 0.04	29.12 ± 0.04
	WT-2	2.49 ± 0.07	29.15 ± 0.03
	WT-3	2.49 ± 0.05	29.26 ± 0.04
A2058G mutated ribosome fragment	MUT-1	2.64 ± 0.05	29.05 ± 0.03
	MUT-2	2.59 ± 0.06	29.00 ± 0.03
	MUT-3	2.63 ± 0.05	29.00 ± 0.03

The average RMSD values (from the production trajectory but relative to the starting structure) and average R_G values (both with standard deviation) are calculated for the C_α and P atoms. The simulated system is shown in Fig. S1