Table 2.

Hazard ratio (95% CI) of all cause mortality according to predicted fat mass and lean body mass in men (Health Professionals Follow-up Study, 1987-2012)

	No of deaths	Incidence rate per 100 000 person years	Hazard ratio (95% CI)
			Model 1*	Model 2†	Model 3‡
Fifth of fat mass §
1 (lowest)	1937	1265	1 (reference)	1 (reference)	1 (reference)
2	2298	1504	1.09 (1.03 to 1.16)	1.06 (1.00 to 1.12)	1.08 (1.01 to 1.15)
3	2297	1504	1.03 (0.97 to 1.09)	0.98 (0.92 to 1.04)	1.01 (0.94 to 1.07)
4	2726	1789	1.23 (1.16 to 1.31)	1.13 (1.06 to 1.20)	1.16 (1.09 to 1.24)
5 (highest)	3098	2038	1.51 (1.42 to 1.60)	1.33 (1.25 to 1.41)	1.35 (1.26 to 1.46)
P value for trend			<0.001	<0.001	<0.001
Fifth of lean body mass §
1 (lowest)	2996	1969	1 (reference)	1 (reference)	1 (reference)
2	2419	1585	0.93 (0.88 to 0.98)	0.93 (0.88 to 0.98)	0.92 (0.87 to 0.97)
3	2324	1521	0.95 (0.90 to 1.01)	0.93 (0.88 to 0.98)	0.90 (0.85 to 0.96)
4	2282	1494	1.03 (0.98 to 1.09)	1.00 (0.95 to 1.06)	0.92 (0.87 to 0.98)
5 (highest)	2335	1529	1.26 (1.20 to 1.34)	1.16 (1.10 to 1.23)	0.97 (0.91 to 1.04)
P value for trend	-	-	<0.001	<0.001	0.49

^*Adjusted for age.

^†Adjusted for age, race (white or non-white), family history of cardiovascular disease (yes or no), family history of cancer (yes or no), physical activity (<3, 3-8.9, 9-17.9, 18-26.9, or >27 MET-h/week), alcohol consumption (0, 0.1-4.9, 5-9.9, 10-14.9, or ≥15 g/day), total energy intake (fifths), smoking status (never, ever, 1-14, 15-24, or ≥25 cigarettes/day), and Alternate Healthy Eating Index (fifths).

^‡Additionally, mutually adjusted for predicted fat mass and predicted lean body mass.

^§Derived from validated anthropometric prediction equations; height was adjusted by inclusion as continuous variable for fat mass and by regression out of variation due to height for lean body mass.