Figure 7.

Increased ATP2a2 activity could rescue glucose intolerance in Ei24 KO mice. A and B, GTT in 10-week-old male mice (A) and female mice (B) that were intraperitoneally injected with CDN1163 or a vehicle once a day for a total of 10 days. Five days later, ITT was performed on the male (C) and female (D) mice. Black solid lines, WT mice with DMSO treatment (n = 8); black dashed lines, KO mice with DMSO treatment (n = 8); red solid lines, WT mice with CDN1163 treatment (n = 8); red dashed lines, KO mice with CDN1163 treatment (n = 8). *, p < 0.05; **, p < 0.01, KO mice with DMSO treatment versus KO mice with CDN1163 treatment. Error bars, S.D.