Figure 1.

Structure of profilin-1 (Protein Data Bank code 1PFN) color-coded to illustrate residues for which either fALS-related mutations (Ala-20, Cys-71, Thr-109, Met-114, Gly-118, in red), benign polymorphisms or moderate risk factors (Glu-117 and Gln-139, in green), or uncertain effect (Arg-136, in orange) have been reported.