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A proposed model for regulation of the inflammatory response by CRBN. CRBN assembles to an active E3 ligase with DDB1, Cul4A, and ROC1; promotes c-Jun ubiquitination; and mediates its degradation by the 26S proteasome. The reduction of c-Jun protein diminishes AP-1 transcriptional activity and thus reduces LPS-stimulated expression of inflammatory cytokines such as iNOS, COX-2, IL-1β, IL-6, etc.
