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. 2018 Jul 3;15:46. doi: 10.1186/s12977-018-0429-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Association of epitope-specific T-cell responses with clinical parameters in HIV-1-infected individuals with the restricting HLA. a T-cell responses to 6 epitope peptides were analyzed by using an IFN-γ ELISPOT assay. The differences in pVL or CD4 count between responders and non-responders to each epitope peptide in the individuals having HLA restriction molecules for the epitopes were statistically analyzed by using the Mann-Whitney test. b Correlation between a breadth of T-cell responses to 5 epitopes (AA9, TL8, WV8, RI8, and HR10) and pVL and CD4 count in 149 individuals carrying the HLA restriction molecules. The correlation was statistically analyzed using Spearman rank test