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. 2018 Jul 3;15:46. doi: 10.1186/s12977-018-0429-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Recognition of mutant epitope peptides by T cells in HIV-1-infected individuals. a Frequencies of TL8 and HR10 mutant epitopes in Japanese individuals. The frequencies of mutant epitopes were investigated from 430 chronically HIV-1-infected Japanese individuals. b The CD8⁺ T-cell responses to the index and mutant epitope peptides in HIV-1-infected Japanese individuals were analyzed by using an IFN-γ ELISPOT assay. The results are shown as mean and SD (n = 3). c The responses of the T cell-lines specific for TL8 or HR10 to wild-type or mutant peptide-prepulsed 721.221 cells expressing the corresponding HLA alleles were analyzed by using the ICS assay. The results are shown as mean and SD (n = 3)