Table 1.
Association of CTL responses to Gag epitopes with pVL and CD4 count
| Epitope | Sequence | HLA | Frequency | Median of pVL | Median of CD4 | P valueb | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Res | Non-res | Res | Non-res | Res | Non-res | pVL | CD4 | |||
| IV9 | IILGLNKIV | A*02 | 2 | 219 | – | – | – | – | – | – |
| FS8 | FLGKIWPS | A*02:01 | 3 | 218 | 910,000 | 55,500 | 629 | 274 | 0.9882 | 0.012 |
| AA9 | ATLEEMMTA | A*02:06 | 16 | 205 | 22,500 | 58,000 | 388 | 269 | 0.0057 | 0.1788 |
| YL9 | YVDRFYKTL | A*02:07 | 2 | 219 | – | – | – | – | – | – |
| SK10 | SILDIKQGPK | A*11:01 | 0 | 221 | – | – | – | – | – | – |
| AK11 | ACQGVGGPGHK | A*11:01 | 4 | 217 | 36,500 | 56,000 | 450 | 274 | 0.3586 | 0.1277 |
| DT9 | DYVDRFYKT | A*24:02 | 1 | 220 | – | – | – | – | – | – |
| ML8 | MYSPTSIL | A*24:02 | 1 | 220 | – | – | – | – | – | – |
| KR9 | KIWPSHKGR | A*31:01 | 0 | 221 | – | – | – | – | – | – |
| IK10 | IAKNCRAPRK | A*31:01 | 9 | 212 | 67,000 | 55,500 | 325 | 275 | 0.4332 | 0.7564 |
| DR11 | DYVDRFYKTLR | A*33:03 | 5 | 216 | 55,000 | 56,000 | 185 | 279 | 0.5951 | 0.3866 |
| GL9 | GPGHKARVL | B*07:02 | 3 | 218 | 38,000 | 56,500 | 646 | 274 | 0.402 | 0.0741 |
| GY9 | GLNKIVRMY | B*15:01 | 13 | 208 | 100,000 | 55,000 | 269 | 285 | 0.6736 | 0.8588 |
| NY10 | NPPIPVGEIY | B*35:01 | 1 | 220 | – | – | – | – | – | – |
| TL8 | TERQANFL | B*40:02 | 23 | 198 | 45,000 | 59,500 | 416 | 275 | 0.1029 | 0.0392 |
| WV8 | WMTETLLV | B*52:01 | 22 | 199 | 39,500 | 58,000 | 405 | 269 | 0.0481 | 0.0006 |
| RI8 | RMYSPTSI | B*52:01 | 31 | 190 | 43,000 | 59,500 | 389 | 264 | 0.0414 | 0.0005 |
| TW10 | TSTLQEQIGW | B*58:01 | 2 | 219 | – | – | – | – | – | – |
| NL11 | NPDCKTILRAL | B*67:01 | 1 | 220 | – | – | – | – | – | – |
| YI9 | YSPTSILDI | C*01:02 | 10 | 211 | 123,000 | 55,000 | 214 | 281 | 0.0919 | 0.159 |
| KL9 | KALGPAATL | C*03 | 9 | 212 | 24,000 | 56,000 | 307 | 275 | 0.368 | 0.7865 |
| YL9 | YVDRFYKTL | C*03 | 5 | 216 | 76,000 | 55,500 | 224 | 285 | 0.7639 | 0.6464 |
| KL9 | KALGPAATL | C*08 | 13 | 208 | 24,000 | 58,000 | 320 | 274 | 0.0228 | 0.64 |
| RI9a | RQANFLGKI | A*02:06 | 4 | 217 | 15,000 | 57,000 | 319 | 274 | 0.009 | 0.9741 |
| TM9a | TLQEQIGWM | A*26:02 | 7 | 214 | 39,000 | 57,500 | 410 | 274 | 0.032 | 0.0921 |
| HR10a | HIAKNCRAPR | A*33:03 | 9 | 212 | 4900 | 58,000 | 416 | 273 | 0.0002 | 0.0196 |
aNew epitope
bStatistically analyzed differences in pVL or CD4 count between responders and non-responders by Mann–Whitney test. Italics indicates that differences were statistically significant