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. 2018 Jul 3;16:38. doi: 10.1186/s12964-018-0248-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The mβCTPs selectively inhibit HUVEC tube formation. a Amino-acid sequences of mβCTPs. In each of mβCTPs, a cell-penetrating peptide (CPP) was fused with a short amino-acid sequence from one of the C-termini of integrin β CTs (βCTP), comprising an NxxY/F motif and a proximal S/T cluster. b HUVECs were seeded on polymerized Matrigel with or without the indicated mβCTPs (20 μM at a final concentration) for 8 h. The formed capillary-like tube structures were recorded under an inverted microscope (5× objective). c The capillary-like polygon tubes were quantified. Results were expressed as means ±SD of three or more experiments, and statistical significance was analyzed using Student’s t test (**, p < 0.01)