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. 2018 Jul 3;16:38. doi: 10.1186/s12964-018-0248-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The antiangiogenic mβCTPs show antitumor activity. a 1.2 × 10⁶ of RM1 cancer cells were subcutaneously injected into BALB/c nude mice (n = 6). Starting on day 5, the formed tumor areas were subjected to treatment by local injection of 100 μl of the indicated mβCTP solution (50 μM at a final concentration) every other day. PBS alone was used as a control. Length (l) and width (w) of the formed tumors were measured, and tumor volumes (v) were calculated by using the following formula: v = 0.52(l × w²). b, c The tumor tissues were harvested on day 15 and subjected to IHC staining for CD31, a marker of vascular endothelial cells. Blood vessels in solid tumor tissues were quantified. Scale bar, 50 μm. The results were expressed as means ±SD; statistical significance was analyzed using Student’s t test (**, p < 0.01)