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. 2018 Jul 3;19:157. doi: 10.1186/s12882-018-0957-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — eGFR over time. Tolvaptan has a hemodynamic effect on eGFR (as calculated by the CKD-EPI formula) that occurs acutely after start of the drug, that is reversible after stopping (as can be seen in 2011). After hydrochlorothiazide (HCT) was started in 2015 the rate of eGFR decline seems steeper. Separate trend lines are shown for eGFR decline on tolvaptan monotherapy and for eGFR decline on tolvaptan-HCT combination therapy