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. 2018 Jul 2;84(14):e00086-18. doi: 10.1128/AEM.00086-18

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FIG 10 — Proposed network of transcriptional regulation that involves YAP1, SKN7, HOG1, NOX, GPx3, GLR1, TSA1, and TRR1 and leads to ROS detoxification in A. alternata. Low-level H₂O₂, generated by superoxide dismutases (SOD) from superoxide (O₂⁻) produced by NOX, may serve as a signal that upregulates the expression of YAP1, SKN7, and HOG1, and nuclear localization of these proteins transcriptionally upregulates TSA1, TRR1, GPx3, and GLR1. TSA1 can detoxify H₂O₂ in conjunction with thioredoxin reductase (TRR1) and thioredoxin cycling between reduced thioredoxin (TRX^[red]) and oxidized thioredoxin (TRX^[ox]). GPx3 can detoxify H₂O₂ in conjunction with glutathione reductase (GLR1) and glutathione cycling between reduced glutathione (GSH) and oxidized glutathione (GSSG).