Table 2.
Flea-control efficacy fluralaner-treated cats compared to sham-treated controls in a simulated home environment
| Days pre/post-treatment | Mean flea count (arithmetic/geometric) | % Efficacy (arithmetic/geometric) | t ( df) | P | |
|---|---|---|---|---|---|
| Control groupa | Fluralaner groupa | ||||
| -1 | 18.4/15.9 (9/9) | 25.9/10.6 (9/10) | na | – | – |
| 1 | 2.9/1.9 (6/9) | *0.1/0.1 (1/10) | 96.5/96.1 | t(9.2) = -3.447 | 0.007 |
| 7 | 0.7/0.4 (3/9) | 0.0/0.0 (0/10) | na | – | – |
| 14 | 0.8/0.4 (3/9) | 0.0/0.0 (0/10) | na | – | – |
| 21 | 17.1/12.1 (8/9) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -7.603 | < 0.0001 |
| 28 | 36.6/33.3 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -24.84 | < 0.0001 |
| 35 | 19.2/17.1 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(9.0) = -17.77 | < 0.0001 |
| 42 | 12.2/9.9 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(9.0) = -11.31 | < 0.0001 |
| 49 | 11.0/10.0 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -16.51 | < 0.0001 |
| 56 | 23.1/21.5 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -24.77 | < 0.0001 |
| 63 | 16.8/15.4 (9/9)) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -20.99 | < 0.0001 |
| 70 | 16.4/12.9 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -11.24 | < 0.0001 |
| 77 | 17.7/14.9 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -14.94 | < 0.0001 |
| 84 | 37.0/32.7 (9/9) | **0.0/0.0 (0/10) | 100/100 | t(8.7) = -24.18 | < 0.0001 |
Abbreviations: df degrees of freedom, na not applicable pre-treatment or < 6 control cats were infested and efficacy not calculated
aNumber infested/total number in group
Significantly different from control group: *P = 0.007, **P ≤ 0.001