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. 2018 Jun 26;9:603. doi: 10.3389/fphar.2018.00603

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Copyright © 2018 Li, Liu, Jiao, Qiu, Huang, Xiao, Wu, Wang, Hu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic goodness-of-fit plots for the base model (1) and the final model (2). (A) The individual predicted concentration (IPRED) vs. the observed concentration. (B) The population predicted concentration (PRED) vs. the observed concentration. (C) The PRED vs. the conditional weighted residual errors (CWRES). (D) The time after dose vs. CWRES. The black solid lines are the reference lines, and red solid lines are the loess smooth lines.