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. 2018 Jun 26;9:603. doi: 10.3389/fphar.2018.00603

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Copyright © 2018 Li, Liu, Jiao, Qiu, Huang, Xiao, Wu, Wang, Hu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vancomycin dosage regimen recommended by the six guidelines relative to the regimen recommended by our final model in typical patients when AUC_24h/MIC ≥ 400. The six guides correspond to (1) the FDA labeled dosage (2017), (2) the British National Formulary (2016–2017) and the Blue Book (2016), (3) the Neonatal Formulary (2015), (4) the Red Book (2015), (5) the Pediatric and Neonatal Dosage Handbook (2015-2016), and (6) Neofax (2017). The red and blue lines in (1) and (6) refer to dosage guidelines for patients with a PNA of 7 days and 15 days respectively. The blue lines in (2),(3),(4), and (5) refers to dosage for PNA of both 7 and 15 days. The dark blue smooth curve represents the mean dosage for the present study, and the light blue ribbon corresponds to the 15–85% dosage interval.