Table 3.
Association of p53 expression intensity with clinicopathologic parameters of head and neck Squamous cell carcinoma
| n (%) | P-value | Power of test (%) | |||||
|---|---|---|---|---|---|---|---|
| No intensity (n = 30) | Weak (n = 13) | Intermediate (n = 30) | Strong (n = 48) | Total (n = 121) | |||
| Age group (years) | |||||||
| ≤ 30 | 3 (10) | 0 (0) | 1 (3.3) | 1 (2.1) | 5 (4.1) | 0.445 | 43.47 |
| 31–50 | 15 (50) | 8 (61.5) | 11 (36.7) | 24 (50) | 58 (47.9) | ||
| > 50 | 12 (40) | 5 (38.5) | 18 (60) | 23 (47.9) | 58 (47.9) | ||
| Gender | |||||||
| Male | 25 (83.3) | 11 (84.6) | 22 (73.3) | 31 (64.6) | 89 (73.6) | 0.269 | 38.17 |
| Female | 5 (16.7) | 2 (15.4) | 8 (26.7) | 17 (35.4) | 32 (26.4) | ||
| Nodal stage | |||||||
| N0 | 17 (56.7) | 9 (69.2) | 22 (73.3) | 19 (39.6) | 67 (55.4) | 0.053 | 82.44 |
| N1 | 8 (26.7) | 0 (0) | 2 (6.7) | 8 (16.7) | 18 (14.9) | ||
| N2a | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| N2b | 5 (16.7) | 4 (30.8) | 6 (20) | 17 (35.4) | 32 (26.4) | ||
| N2c | 0 (0) | 0 (0) | 0 (0) | 3 (6.3) | 3 (2.5) | ||
| N3 | 0 (0) | 0 (0) | 0 (0) | 1 (2.1) | 1 (0.8) | ||
| Extranodal extension | |||||||
| Not present | 22 (73.3) | 11 (84.6) | 28 (93.3) | 29 (60.4) | 90 (74.4) | 0.008 | 81.53 |
| Present | 8 (26.7) | 2 (15.4) | 2 (6.7) | 19 (39.6) | 31 (25.6) | ||
| Histologic grade | |||||||
| Grade-I | 6 (20) | 7 (53.8) | 12 (40) | 8 (16.7) | 33 (27.3) | 0.046 | 74.91 |
| Grade-II | 20 (66.7) | 4 (30.8) | 14 (46.7) | 35 (72.9) | 73 (60.3) | ||
| Grade-III | 4 (13.3) | 2 (15.4) | 4 (13.3) | 5 (10.4) | 15 (12.4) | ||
Chi square test was applied
P-value ≤ 0.05 considered as significant