Table 3.

Previous meta-analyses comparing MIPD with OPD for benign and malignant periampullary disease

Variables	Correa	Nigri	Lei	Qin	de Rooij	Zhang	Peng	Shinb	Shinb
Year	2014	2014	2014	2014	2016	2016	2017	2017	2017
Included studies	6	8	9	11	19	22	9	8	5
Minimally invasive method	MIPD	MIPD	MIPD	MIPD	MIPD	MIPD	RPD	LPD	RPD
Total MIPD numbers	169	204	209	327	710	1018	245	450	160
POPF	NS	NS	NS	NS	NS	NS	NS	NS	NS
Morbidity	NS	NS	NS	NSa	N/A	NS	Favor RPD	NS	NSa
Mortality	N/A	NS	NS	NS	NS	NS	NS	N/A	N/A
R0 rate	Favor MIPD	NS	Favor MIPD	NSa	Favor MIPD	Favor MIPD	Favor RPD	NS	NS
Retrieved lymph nodes	Favor MIPD	NSa	NS	NS	NS	NSa	NS	NS	NS
Survival	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Operation time	Favor OPD	Favor OPD	Favor OPD	Favor OPD	Favor OPD	Favor OPD	NS	Favor OPD	Favor OPD
Blood loss	Favor MIPD	Favor MIPD	Favor MIPD	Favor MIPD	Favor MIPD	Favor MIPD	N/A	NS	Favor RPD
Transfusion	N/A	NS	Favor MIPD	N/A	N/A	Favor MIPD	N/A	N/A	N/A
Hospital stay (days)	Favor MIPD	Favor MIPD	Favor MIPD	Favor MIPD	Favor MIPD	Favor MIPD	Favor RPD	Favor LPD	Favor RPD

NS not significant, N/A not available

^a not significant but tended to favor MIPD

^b one separate study