Fig. 1.

Pedigree, chromatograms and filtering procedures in the SH1190831 family. a Pedigree of SH1190831 family is comprised of three generations. The squares and circles indicate males and females, respectively. The arrow appoints the proband of the family. The mutation, c.3835C > T in MYH6, has been demonstrated that segregated in this family. b Sequence chromatogram showing heterozygote state of the nucleotide sequence of MYH6 in c.3835C > T. c Schematic representation of filtering strategies that applied in this research. The filtering process was applied according several strategies which are demonstrated in the schematic representation. For more investigation, we reevaluated the filtering steps by regard to this fact that the disease could be engendered by autosomal recessive; however, we could not detect any relevant variants according to this supposition