Table 3.

Effect of maternal age in childhood solid cancers development.

Diagnosis	Maternal age	N	Unadjusted OR	CI 95%	Adjusted OR ∗	CI 95%
Brain tumor	All ages	62	p-value=0.99 a		p-value=0.97
	<20	5	1.06	0.32-3.46	1.06	0.71-1.55
	20-24	16	2.06	0.80-5.29	1.92	0.27-4.16
	25-29b	14	1		1
	30-34	18	2.10	0.83-5.27	1.42	0.53-3.08
	>35	9	1.26	0.44-3.55	0.88	0.26-2.97
Non-Hodgkin lymphoma	All ages	43	p-value=0.56		p-value=0.80
	<20	1	0.33	0.03-3.08	0.45	0.34-4.50
	20-24	11	1.29	0.47-3.51	1.53	0.54-4.30
	25-29b	13	1		1
	30-34	13	1.69	0.63-4.48	1.61	0.50-4.57
	>35	5	1.00	0.29-3-37	0.91	0.22-3.81
Osteosarcoma	All ages	42	p-value=0.019		p-value=0.054
	<20	3	0.85	0.34-2.56	0.60	0.40-3.09
	20-24	16	0.70	0.24-2.04	0.58	0.16-2.08
	25-29b	10	1		1
	30-34	8	1.38	0.52-3.64	0.99	0.62-2.30
	>35	5	1.91	1.12-3.09	1.35	0.81-2.33
Wilms tumor	All ages	35	p-value=0.954		p-value=0.346
	<20	1	-		-
	20-24	10	2.47	0.73-8.39	2.76	0.75-10.17
	25-29b	5	1		1
	30-34	9	3.71	0.96-14.30	3.18	0.73-13.83
	>35	10	1.52	0.43-5.39	0.91	0.22-3.73
Ewing's sarcoma	All ages	24	p-value=0.713		p-value=0.543
	<20	2	0.78	0.11-5.26	0.65	0.07-5.35
	20-24	7	1.24	0.32-4.76	1.51	0.31-7.37
	25-29b	7	1		1
	30-34	3	0.35	0-07-1.60	2.73	0.51-1.33
	>35	5	1.46	0.26-8.11	1.05	0.18-6.06
Soft tissue sarcoma	All ages	24	p-value=0.567		p-value=0.33
	<20	0
	20-24	6	1.58	0.31-8.01	1.40	0.26-7.39
	25-29b	7	1		1
	30-34	6	0.92	0.24-3.47	1.45	0.29-7.09
	>35	5	2.04	0.47-8.78	1.59	0.45-8.59
Gonadal germinal tumor	All ages	21	p-value: 0.15		p-value=0.54
	<20	1
	20-24	8	2.03	0.33-12.38	2.45	0.28-20.88
	25-29b	3	1		1
	30-34	6	1.92	0.25-14.3	1.37	0.17-10.94
	>35	3	0.85	0.11-6.12	0.76	0.09-6.37
Retinoblastoma	All ages	16	p-value=0.04		p-value=0.037
	<20	0
	20-24	5	2.30	0.29-4.83	0.26	0.20-3.53
	25-29b	3	1		1
	30-34	3	1.00	0.47-5.28	1.09	0.41-4.07
	>35	5	1.51	0.67-8.19	1.21	1.09-6.08
Hepatoblastoma	All ages	16	p-value= 0.587		p-value=0.07
	<20	1	0.54	0.03-8.10	-
	20-24	2	0.55	0.05-5.67	1.02	0.07-14-12
	25-29b	3	1		1
	30-34	4	0.84	0.14-4.89	1.91	0.23-15.31
	>35	6	1.27	0.25-6.31	4.35	0.31-60.38
Hodgkin lymphoma	All ages	14	p-value=0.192		p-value=0.196
	<20	2	5.08	0.34-75.08	5.58	0.20-14.93
	20-24	6	2.40	0.37-15.71	1.87	0.26-13.41
	25-29b	2	1		1
	30-34	4	2.89	0.35-23.39	1.03	0.08-13.10
	>35	0
Neuroblastoma	All ages	12	p-value=0.898		p-value=0.51
	<20	1	-		-
	20-24	1	-		-
	25-29b	5	1		1
	30-34	4	0.66	0.054-8-07	1.91	0.24-15.10
	>35	1	-		0.76	0.04-14.02

∗ Adjusted by paternal age, number of siblings, and level of maternal and paternal education.

Significant results are bolded.

a denotes where age groups are taken to be continuous in all cancers.

b denotes reference group.