Table 4.

Effect of paternal age in childhood solid cancers development.

Diagnosis	Paternal age	N	Unadjusted OR	CI 95%	Adjusted OR ∗	CI 95%
Brain tumor	All ages	62	p-value=0.94 a		p-value=0.98
	<20	5	0.44	0.02-4.57	0.33	0.02-3.89
	20-24	16	1.12	0-42-3.01	1.01	0.36-2.83
	25-29b	14	1		1
	30-34	18	0.90	0.33-2.4	0.91	0.30-2.73
	>35	9	0.90	0.36-2.19	0.99	0.34-2.85
Non-Hodgkin lymphoma	All ages	43	p-value=0.09		p-value=0.047
	<20	1	-		-
	20-24	11	0.24	0.06-0.96	0.19	0.03-0.97
	25-29b	13	1		1
	30-34	13	0.54	0.17-1.73	0.37	0.09-1.43
	>35	5	0.48	0.17-1.34	0.36	0.82-1.64
Osteosarcoma	All ages	42	p-value=0.10		p-value=0.23
	<20	3	-		-
	20-24	16	5.70	0.98-33.0	3.10	0.94-8.6
	25-29b	10	1		1
	30-34	8	1.80	0.55-5.24	1.15	0.32-4.05
	>35	5	1.35	0.46-3.97	0.92	0.27-3.1
Wilms tumor	All ages	35	p-value=0.31		p-value=0.39
	<20	1	-		-
	20-24	10	0.41	0.06-2.61	0.36	0.05-2.51
	25-29b	5	1		1
	30-34	9	1.05	0.26-4.17	1.30	0.30-5.59
	>35	10	1.43	0.42-4.92	2.06	0.41-10.16
Ewing's sarcoma	All ages	24	p-value=0.36		p-value=0.52
	<20	2	-		-
	20-24	7	1.01	0.14-7.12	1.00	0.13-7.22
	25-29b	7	1		1
	30-34	3	0.89	0.24-3.23	0.66	0.13-3.37
	>35	5	0.38	0.07-1.88	0.25	0.03-2.01
Soft tissue sarcoma	All ages	24	p-value=0.43		p-value=0.38
	<20	0	-		-
	20-24	6	0.33	0.28-4.11	0.91	0.4-18.3
	25-29b	7	1		1
	30-34	6	0.48	0.11-2.02	0.76	0.13-4.3
	>35	5	0.42	0.12-1.45	0.25	0.02-1.86
Gonadal germinal tumor	All ages	21	p-value=0.03		p-value=0.04
	<20	1	-		-
	20-24	8	2.74	0-35-20.41	2.09	0.16-26.03
	25-29b	3	1		1
	30-34	6	1.52	1.29-19.4	5.71	1.76-14.41
	>35	3	1.37	0.22-8.53	5.82	0.32-10.36
Retinoblastoma	All ages	16	p-value=0-03		p-value=0.005
	<20	0
	20-24	5	1.96	0.39-4.34	3.37	0.24-4.81
	25-29b	3	1		1
	30-34	3	2.11	0.28-15.75	1.37	0.59-12.19
	>35	5	2.10	1.21-15.04	1.17	1.01-16.33
Hepatoblastoma	All ages	16	p-value=0.16		p-value=0.21
	<20	1	-		-
	20-24	2	-		-
	25-29b	3	1		1
	30-34	4	0.18	0.017-1.96	0.10	0.01-1.55
	>35	6	0.21	0.02-2.11	0.10	0.01-1.80
Hodgkin lymphoma	All ages	14	p-value=0.97		p-value=0.47
	<20	2	0.72	0.03-16.01	0.24	0.01-11.58
	20-24	6	1.25	0.15-10.43	0.50	0.02-8.60
	25-29b	2	1		1
	30-34	4	0.52	0.03-7.16	0.89	0.06-12.85
	>35	0	1.59	0.16-15.7	1.96	0.13-28.8
Neuroblastoma	All ages	12	p-value=0.13		p-value=0.48
	<20	1	-		-
	20-24	1	5.26	0.13-19.05	5.4	0.12-22.24
	25-29b	5	1		1
	30-34	4	3.10	0.21-45.23	2.08	0.17-35.38
	>35	1	0.54	0.06-4.33	0.28	0.01-4.38

∗ Adjusted by maternal age, number of siblings, and level of maternal and paternal education.

Significant results are bolded.

a denotes where age groups are taken to be continuous in all cancers.

b denotes reference group.