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. Author manuscript; available in PMC: 2019 Apr 5.
Published in final edited form as: Cell. 2018 Apr 5;173(2):371–385.e18. doi: 10.1016/j.cell.2018.02.060

Figure 5. Hypermutators exhibit multiple signatures, microsatellite instability, and immune infiltration expression.

Figure 5

(A) UpSetR(Conway et al., 2017) plot highlights the intersection of multiple signatures and phenotypes with hypermutated samples. (B) MSI scores segregated by cancer types. MSI-score threshold is displayed with a vertical line. The percentage of samples with high MSI is displayed to the right of each cancer type. (C, D) RNA-Seq abundance of different immune biomarkers across signatures and MSI phenotypes defined by MSIsensor. Stars indicate significance levels using a two-sided t-test to calculate p-values (* < 0.05, ** < 0.01, *** < 0.001). See also Figure S6 and Table S5.