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. 2018 Jun 19;2018:5050469. doi: 10.1155/2018/5050469

Figure 5.

Figure 5

Expression levels for some inflammation cytokines in the rat cortex in penumbral and stroke areas were quantified by IOD with Image Pro Plus 6.0 software. (a) DAHP downregulated the caspase-3 expression (∗P < 0.05, versus the DAHP-treated group). Ischemic reperfusion induced a substantial caspase-3 expression (#P < 0.05, versus the sham group), which was significantly attenuated by DAHP but not vehicle treatment and MCAO groups (n = 4, ∗P < 0.05, versus the DAHP-treated group). (b) DAHP increased Bcl-2 expression. The total Bcl-2 expression was significantly increased 24 h after ischemic reperfusion in the DAHP group (n = 4, ∗P < 0.05, versus the DAHP-treated group), relative to MCAO or vehicle treatment. (c) DAHP reduced TNF-α expression. Ischemic reperfusion induced a substantial increase in TNF-α expression (#P < 0.05, versus the sham group), which reduced in the DAHP-treated group (n = 3, ∗P < 0.05, versus the DAHP-treated group). (d) DAHP attenuated iNOS expression. Ischemic reperfusion induced a substantial increase in iNOS expression (#P < 0.05, versus the sham group), which was significantly attenuated by DAHP (n = 4, ∗P < 0.05, versus the DAHP-treated group). (e) DAHP induced COX-2 expression; DAHP increased COX-2 expression (n = 4, ∗P < 0.05, versus the DAHP-treated group).