Figure 5.
Expression levels for some inflammation cytokines in the rat cortex in penumbral and stroke areas were quantified by IOD with Image Pro Plus 6.0 software. (a) DAHP downregulated the caspase-3 expression (∗P < 0.05, versus the DAHP-treated group). Ischemic reperfusion induced a substantial caspase-3 expression (#P < 0.05, versus the sham group), which was significantly attenuated by DAHP but not vehicle treatment and MCAO groups (n = 4, ∗P < 0.05, versus the DAHP-treated group). (b) DAHP increased Bcl-2 expression. The total Bcl-2 expression was significantly increased 24 h after ischemic reperfusion in the DAHP group (n = 4, ∗P < 0.05, versus the DAHP-treated group), relative to MCAO or vehicle treatment. (c) DAHP reduced TNF-α expression. Ischemic reperfusion induced a substantial increase in TNF-α expression (#P < 0.05, versus the sham group), which reduced in the DAHP-treated group (n = 3, ∗P < 0.05, versus the DAHP-treated group). (d) DAHP attenuated iNOS expression. Ischemic reperfusion induced a substantial increase in iNOS expression (#P < 0.05, versus the sham group), which was significantly attenuated by DAHP (n = 4, ∗P < 0.05, versus the DAHP-treated group). (e) DAHP induced COX-2 expression; DAHP increased COX-2 expression (n = 4, ∗P < 0.05, versus the DAHP-treated group).