. 2018 Jun 19;2018:7807245. doi: 10.1155/2018/7807245

Table 2.

Chronic effects of exercise on circulating extracellular vesicles.

Author (year)	Exercise dose	Subtype EV	Preanalytical phase	Collection time	Response
La Vignera et al. [87]	150 min aerobic activity/wk for 3 mo in individuals with and without erectile dysfunction.	CD45⁻/CD34⁻/CD144⁺	Specifics not reported	(i) Baseline (ii) 3 mo	↓CD45⁻/CD34⁻/CD144⁺

Babbitt et al. [90]	24 wk aerobic training, 3x/wk, 40 min at 65% VO₂peak in sedentary, middle-aged African American adults.	CD62E⁺	2000g for 20 min at 4°C	(i) Baseline (ii) 6 mo	↓CD62E⁺

Kretzschmar et al. [89]	6 mo aerobic training, 3x/wk, 40 min at 65% VO₂peak in pre- and postmenopausal African American women.	CD62E⁺ CD31⁺/CD42b⁻	Double centrifugation at 1500g for 20 min at 24°C	(i) Baseline (ii) 6 mo	↓CD62E⁺ ↓CD31⁺/CD42b⁻ in the premenopausal group only

Bruyndonckx et al. [86]	10 months of 3 supervised sessions/wk combined with diet intervention in obese children between the ages of 12 and 18.	CD31⁺/CD42b⁻	Double centrifugation of 1525g for 20 min	(i) Baseline (ii) 5 mo (iii) 10 mo	↓CD31⁺/CD42b⁻

Kim et al. [88]	3 days/wk for 6 mo of 40 min at 65% of predicted HR_peak in adults with prehypertension.	CD31⁺/CD42b⁻, CD62E⁻	Double centrifugation of 1500g for 20 min	(i) Baseline (ii) 6 mo	↓CD31⁺/CD42a⁻ ↓CD62E⁺

Pitha et al. [91]	6 mo of supervised training on a cycle ergometer in renal transplant recipients.	CD34⁺ CD45⁺	ELISA	(i) Baseline (ii) Median of 6 mo	No change

Van Craenenbroeck et al. [95]	12 wk, 3x/wk aerobic continuous training (70–75% HR_peak) or aerobic interval training (four 4 min intervals 90–95% of HR_peak with 3 min recovery at 50–70% of HR_peak) adults with coronary artery disease.	CD31⁺/CD42b⁻	Double centrifugation at 1550g	(i) Baseline (ii) 12 wk	No change