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Male Townes HbSS mice display evoked pain hypersensitivity. Paw withdrawal frequencies (PWF) to a 0.16 g low force (A) and a 0.4 g medium force (B) von Frey filaments and paw withdrawal latencies (PWL) to thermal (C) and cold (D) stimuli on both left and right hind paws of 4 month old male HbAA and HbSS mice. n = 10 mice/genotype, **P< 0.01 vs. the corresponding HbAA group.
