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. 2018 Mar 15;103(7):1124–1135. doi: 10.3324/haematol.2017.187013

Figure 2.

Figure 2.

Townes HbSS DRG neurons display increased excitability and spontaneous activity. (A and B) Resting membrane potential (RMP, A) and current threshold for pulse (Ithreshold, B). n = 24 large, 22 medium, and 21 small neurons from the HbAA group (7 mice). n = 25 large, 23 medium, and 25 small neurons from the HbSS group (6 mice). **P<0.01 vs. the corresponding HbAA group. (C) Representative trace of evoked action potentials in small DRG neurons. (D) Numbers of evoked action potentials (APs) in large, medium, and small DRG neurons from the HbAA and HbSS groups after application of different currents as indicated. Numbers of the recorded neurons are the same as in A. *P<0.05, **P<0.01 vs. the same stimulation intensity in the HbAA group. (E) Representative trace of spontaneous activity in small DRG neurons from the HbAA and HbSS groups. (F and G) Percentage of DRG neurons that had spontaneous activity (SA, F) and frequency of spontaneous activity (G). n = 23 large, 22 medium, and 25 small DRG neurons for the HbAA group (7 mice). n = 26 large, 25 medium, and 22 small DRG neurons from the HbSS group (6 mice). *P<0.05, **P<0.01 vs. the corresponding HbAA group.