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. 2018 Mar 15;103(7):1124–1135. doi: 10.3324/haematol.2017.187013

Figure 3.

Figure 3.

Hindpaw administration of ABT-627 can alleviate pain hypersensitivity and spontaneous ongoing pain under normoxic and hypoxic conditions in male HbSS mice. (A–D) Effect of hindpaw injection of ABT-627 on paw withdrawal frequencies (PWF) to a 0.16 g low force (A) and a 0.4g medium force (B) and paw withdrawal latencies (PWL) to heat (C) and cold (D) stimuli on the ipsilateral side of HbAA mice and HbSS mice under normoxic and hypoxic conditions. Veh: vehicle. ABT: ABT-627. n=6 mice/genotype/treatment. *P<0.05, **P<0.01 vs. the corresponding HbAA group. ##P<0.01 vs. the HbSS baseline value. $P<0.05 vs. the corresponding vehicle-treated HbSS group. (E and F) Effect of hindpaw injection of ABT-627 (ABT) on ongoing pain as assessed by the conditioned place preference paradigm. n=6-8 mice/group. **P<0.01 vs. the corresponding pre-conditioning (E) or the HbAA plus vehicle (Vel) group (F). ##P<0.01 vs. the corresponding post-conditioning (post) from the HbSS plus vehicle group or the HbSS plus vehicle group (F).