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. 2018 Mar 15;103(7):1124–1135. doi: 10.3324/haematol.2017.187013

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Figure 4. — Male HbSS mice with conditional genetic knockdown of DRG ET_A receptors fail to develop pain hypersensitivity before and after hypoxia/reoxygenation exposure. Paw withdrawal frequency (PWF) in response to a 0.16 g low mechanical force (A) and a 0.4 g medium mechanical force (B) and paw withdrawal latency (PWL) in response to heat (C) and cold (D) stimuli on both left and right sides of ET_A^fl/fl mice and ET_A^cre/fl mice 2 months after BerkSS (SS) or BerkAA (AA) bone marrow transplantation (BMT). n = 6-8 mice/group. **P<0.01 vs. the corresponding baseline value. ^##P<0.01 vs. the corresponding BMT + Normoxia value.