Table 1. Clinical diagnostic criteria for tuberous sclerosis complex: 2012 consensus guidelines [8].

Major features	Minor features
Hypomelanotic macules (≥ 3, at least 5 mm in diameter)	“Confetti” skin lesions
Angiofibromas (≥ 3) or fibrous cephalic plaque	Dental enamel pits (> 3)
Ungual fibromas (≥ 2)	Intraoral fibromas (≥ 2)
Shagreen patch	Retinal achromic patch
Multiple retinal hamartomas	Multiple renal cysts
Cortical dysplasias	Nonrenal hamartomas
Subependymal nodules
Subependymal giant cell astrocytoma
Cardiac rhabdomyoma
Lymphangioleiomyomatosis
Angiomyolipomas (≥ 2)

Definite diagnosis: Two major features or 1 major feature with ≥ 2 minor features. Possible diagnosis: Either 1 major feature or ≥ 2 minor features.