Table 4.
Dynamics of changes in psychometric scales and side effect rating scale scores on days 5 to 14 of the inpatient treatment course in patients with different genotypes of CYP2D6 gene by polymorphic marker 1846G>A
| Scale | GG | GA | P-value |
|---|---|---|---|
| SoPA | 12.000 [10.000; 13.000] | 6.000 [3.000; 9.000] | 0.000 |
| PACS | 7.000 [6.000; 8.000] | 3.000 [2.000; 4.000] | 0.000 |
| VAS | 18.000 [13.000; 27.000] | 17.000 [6.000; 22.000] | 0.202 |
| CGI | 2.000 [1.000; 3.000] | 1.000 [0.000; 1.000] | 0.000 |
| HADS | 17.000 [15.000; 24.000] | 7.000 [4.000; 11.000] | 0.000 |
| HAM-D | 11.000 [10.000; 13.000] | 6.000 [5.000; 9.000] | 0.003 |
| BDI | 32.000 [28.000; 39.000] | 16.000 [13.000; 19.000] | 0.000 |
| UKU | 5.000 [3.000; 5.000] | 8.000 [8.000; 9.000] | 0.000 |
Note: Data has been presented in as median and interquartile range.
Abbreviations: BDI, Beck Depression Inventory; CGI, Clinical Global Impression; HADS, Hospital Anxiety and Depression Scale; HAM-D, Hamilton Rating Scale for Depression; PACS, Penn Alcohol Craving Scale; SoPA, Scale of Pathological Addiction; UKU, The UKU Side Effect Rating Scale; VAS, Visual Analog Scale.