Table S2.
Stratified hazard ratio (95% CI) of coronary heart disease according to total glucosinolate intake by various characteristics of participantsa
| Variables | Quintiles of total glucosinolate intake
|
Ptrend | Pinteractionb | ||||
|---|---|---|---|---|---|---|---|
| 1 (low) | 2 | 3 | 4 | 5 (high) | |||
| Race | >0.99 | ||||||
| Caucasians | 1 | 0.97 (0.90, 1.04) | 0.99 (0.92, 1.06) | 1.05 (0.98, 1.13) | 1.09 (1.01, 1.17) | 0.001 | |
| Other races | 1 | 0.63 (0.39, 1.02) | 0.85 (0.54, 1.34) | 0.98 (0.64, 1.51) | 0.95 (0.62, 1.46) | 0.34 | |
| Age (years) | 0.77 | ||||||
| <65 | 1 | 1.03 (0.91, 1.17) | 1.07 (0.94, 1.21) | 1.13 (0.99, 1.28) | 1.12 (0.98, 1.28) | 0.06 | |
| ≥65 | 1 | 0.91 (0.83, 0.99) | 0.95 (0.87, 1.04) | 1.03 (0.94, 1.12) | 1.06 (0.97, 1.16) | 0.01 | |
| BMI (kg/m2) | 0.58 | ||||||
| <30 | 1 | 1.00 (0.99, 1.01) | 0.94 (0.87, 1.02) | 0.98 (0.91, 1.06) | 1.06 (0.98, 1.15) | 0.003 | |
| ≥30 | 1 | 1.03 (0.88, 1.20) | 0.99 (0.85, 1.15) | 1.00 (0.86, 1.16) | 1.11 (0.95, 1.29) | 0.20 | |
| Modified AHEI score | 0.57 | ||||||
| <Median level | 1 | 0.94 (0.85, 1.04) | 1.00 (0.90, 1.11) | 1.00 (0.89, 1.12) | 1.11 (0.97, 1.27) | 0.12 | |
| ≥Median level | 1 | 1.02 (0.93, 1.13) | 1.02 (0.93, 1.12) | 1.12 (1.02, 1.23) | 1.14 (1.05, 1.25) | <0.001 | |
| Physical activity | 0.33 | ||||||
| <Median level | 1 | 1.02 (0.93, 1.11) | 1.03 (0.94, 1.12) | 1.11 (1.01, 1.21) | 1.13 (1.03, 1.24) | 0.005 | |
| ≥Median level | 1 | 0.89 (0.80, 0.99) | 0.93 (0.84, 1.04) | 1.00 (0.90, 1.11) | 1.05 (0.94, 1.17) | 0.04 | |
| Smoking status | 0.50 | ||||||
| Never | 1 | 0.96 (0.89, 1.03) | 0.99 (0.91, 1.06) | 1.07 (0.99, 1.15) | 1.09 (1.01, 1.18) | 0.001 | |
| Ever | 1 | 0.95 (0.80, 1.13) | 0.97 (0.82, 1.16) | 0.96 (0.80, 1.15) | 1.07 (0.89, 1.29) | 0.36 | |
| Alcohol consumption | 0.91 | ||||||
| Never | 1 | 1.01 (0.91, 1.13) | 0.99 (0.89, 1.11) | 1.05 (0.94, 1.17) | 1.10 (0.99, 1.23) | 0.06 | |
| Ever | 1 | 0.92 (0.84, 1.01) | 0.98 (0.89, 1.07) | 1.06 (0.97, 1.16) | 1.08 (0.98, 1.18) | 0.004 | |
Notes:
Estimates are calculated in Cox proportional hazards models, adjusted for age (years), ethnicity (Caucasian, African American, Asian, and other ethnicity), family history of myocardial infarction (yes/no), hypertension (yes/no), hypercholesterolemia (yes/no), smoking status (never, former, current [1–14, 15–24, or ≥25 cigarettes/day], or missing), alcohol intake (0, 0.1–4.9, 5.0–14.9, and ≥15.0 g/day for women, 0, 0.1–4.9, 5.0–29.9, and ≥30.0 g/day for men, or missing), physical activity (<3.0, 3.0–8.9, 9.0–17.9, 18.0–26.9, ≥27.0 MET-hours/week, or missing), menopausal status and postmenopausal hormone use (premenopause, postmenopause [never, former, or current hormone use], or missing, for women), oral contraceptive use (yes, no, or missing, for Nurses’ Health Study II), multivitamin use (yes/no), BMI (<23, 23–24.9, 25–29.9, 30–34.9, ≥35 kg/m2, or missing), and total energy intake (kcal/day), and the modified AHEI score (quintiles).
Pinteraction was calculated using the likelihood ratio test.
Abbreviations: AHEI, Alternative Healthy Eating Index; BMI, body mass index; MET, metabolic equivalents of task.