Table S3.

Sensitivity analyses for the association between total glucosinolate intake and coronary heart disease in three cohorts^a

Variables	Quintiles of intake					Ptrend	Every SD increment
	1 (low)	2	3	4	5 (high)
Using baseline glucosinolate intake as an exposure	1	0.93 (0.86, 0.99)	0.96 (0.89, 1.03)	1.03 (0.96, 1.11)	1.04 (0.97, 1.12)	0.01	1.03 (1.01, 1.05)
Adjustment for major dietary factors instead of modified AHEI score	1	0.95 (0.89, 1.02)	0.98 (0.91, 1.05)	1.04 (0.97, 1.12)	1.06 (0.98, 1.14)	0.02	1.02 (0.99, 1.04)
Continuing updating diet after diagnosis of cardiovascular disease or cancer	1	0.96 (0.90, 1.03)	1.01 (0.94, 1.08)	1.06 (0.99, 1.14)	1.10 (1.02, 1.18)	<0.001	1.03 (1.00, 1.05)
Using a 4-year lag period	1	0.94 (0.87, 1.01)	0.99 (0.92, 1.06)	1.06 (0.98, 1.14)	1.06 (0.99, 1.15)	0.008	1.03 (1.01, 1.05)
Using an 8-year lag period	1	0.94 (0.87, 1.02)	0.98 (0.91, 1.06)	1.04 (0.96, 1.13)	1.05 (0.97, 1.14)	0.03	1.03 (1.00, 1.05)

Notes:

^aEstimates are calculated in Cox proportional hazards models, adjusted for age (years), ethnicity (Caucasian, African American, Asian, and other ethnicity), family history of myocardial infarction (yes/no), hypertension (yes/no), hypercholesterolemia (yes/no), smoking status (never, former, current [1–14, 15–24, or ≥25 cigarettes/day], or missing), alcohol intake (0, 0.1–4.9, 5.0–14.9, and ≥15.0 g/day for women, 0, 0.1–4.9, 5.0–29.9, and ≥30.0 g/day for men, or missing), physical activity (<3.0, 3.0–8.9, 9.0–17.9, 18.0–26.9, ≥27.0 MET-hours/week, or missing), menopausal status and postmenopausal hormone use (premenopause, postmenopause [never, former, or current hormone use], or missing, for women), oral contraceptive use (yes, no, or missing, for Nurses’ Health Study II), multivitamin use (yes/no), BMI (<23, 23–24.9, 25–29.9, 30–34.9, ≥35 kg/m², or missing), and total energy intake (kcal/day), and the modified AHEI score (quintiles).

Abbreviations: AHEI, Alternative Healthy Eating Index; BMI, body mass index; MET, metabolic equivalents of task.