Table S4.
HR (95% CI) of coronary heart disease according to quintiles of main individual glucosinolatesa
| Quintiles of intake
|
Ptrend | |||||
|---|---|---|---|---|---|---|
| 1 (low) | 2 | 3 | 4 | 5 (high) | ||
| Glucobrassicin | ||||||
| NHS | 1 | 0.96 (0.86, 1.07) | 1.06 (0.96, 1.18) | 1.09 (0.98, 1.21) | 1.09 (0.98, 1.22) | 0.03 |
| NHSII | 1 | 1.03 (0.81, 1.32) | 0.88 (0.68, 1.13) | 1.05 (0.82, 1.34) | 1.06 (0.83, 1.35) | 0.57 |
| HPFS | 1 | 0.92 (0.83, 1.01) | 0.94 (0.85, 1.04) | 1.02 (0.93, 1.13) | 1.01 (0.91, 1.11) | 0.28 |
| Pooled resultsb | 1 | 0.95 (0.88, 1.01) | 0.99 (0.92, 1.06) | 1.05 (0.98, 1.13) | 1.05 (0.97, 1.12) | 0.02 |
| Sinigrin | ||||||
| NHS | 1 | 1.04 (0.93, 1.17) | 1.09 (0.97, 1.22) | 1.15 (1.03, 1.28) | 1.35 (1.21, 1.51) | <0.001 |
| NHSII | 1 | 1.21 (0.94, 1.56) | 1.20 (0.93, 1.55) | 1.16 (0.89, 1.51) | 1.28 (1.00, 1.65) | 0.13 |
| HPFS | 1 | 0.96 (0.87, 1.06) | 0.93 (0.84, 1.03) | 0.98 (0.89, 1.08) | 1.05 (0.96, 1.16) | 0.09 |
| Pooled resultsb | 1 | 1.01 (0.94, 1.09) | 1.01 (0.94, 1.09) | 1.06 (0.99, 1.14) | 1.19 (1.11, 1.27) | <0.001 |
| Glucoraphanin | ||||||
| NHS | 1 | 1.00 (0.90, 1.10) | 1.05 (0.94, 1.16) | 0.89 (0.79, 0.99) | 0.93 (0.83, 1.04) | 0.04 |
| NHSII | 1 | 0.95 (0.75, 1.20) | 0.95 (0.75, 1.21) | 0.81 (0.62, 1.05) | 1.00 (0.78, 1.27) | 0.99 |
| HPFS | 1 | 0.92 (0.84, 1.01) | 0.97 (0.88, 1.07) | 0.96 (0.87, 1.06) | 1.02 (0.92, 1.12) | 0.33 |
| Pooled resultsb | 1 | 0.96 (0.89, 1.02) | 1.00 (0.93, 1.07) | 0.92 (0.86, 0.99) | 0.98 (0.91, 1.05) | 0.64 |
| Glucoiberin | ||||||
| NHS | 1 | 0.98 (0.87, 1.09) | 1.08 (0.97, 1.20) | 1.05 (0.94, 1.18) | 1.19 (1.06, 1.32) | <0.001 |
| NHSII | 1 | 1.12 (0.88, 1.42) | 0.91 (0.70, 1.18) | 0.97 (0.75, 1.26) | 1.20 (0.94, 1.53) | 0.16 |
| HPFS | 1 | 0.94 (0.86, 1.04) | 0.97 (0.88, 1.07) | 1.04 (0.94, 1.14) | 0.99 (0.90, 1.10) | 0.55 |
| Pooled resultsb | 1 | 0.97 (0.91, 1.04) | 1.01 (0.94, 1.08) | 1.04 (0.97, 1.11) | 1.09 (1.01, 1.17) | 0.004 |
| Neoglucobrassicin | ||||||
| NHS | 1 | 1.00 (0.91, 1.11) | 1.05 (0.95, 1.17) | 0.90 (0.81, 1.01) | 0.95 (0.85, 1.06) | 0.09 |
| NHSII | 1 | 1.09 (0.87, 1.38) | 0.97 (0.76, 1.24) | 0.83 (0.63, 1.08) | 1.05 (0.82, 1.34) | 0.97 |
| HPFS | 1 | 0.94 (0.85, 1.03) | 0.96 (0.87, 1.05) | 0.97 (0.88, 1.07) | 1.02 (0.92, 1.12) | 0.34 |
| Pooled resultsb | 1 | 0.98 (0.91, 1.05) | 1.00 (0.93, 1.07) | 0.93 (0.87, 1.00) | 0.99 (0.92, 1.06) | 0.76 |
Notes:
Estimates are calculated in Cox proportional hazards models, adjusted for age (years), ethnicity (Caucasian, African American, Asian, and other ethnicity), family history of myocardial infarction (yes/no), hypertension (yes/no), hypercholesterolemia (yes/no), smoking status (never, former, current [1–14, 15–24, or ≥25 cigarettes/day], or missing), alcohol intake (0, 0.1–4.9, 5.0–14.9, and ≥15.0 g/day for women, 0, 0.1–4.9, 5.0–29.9, and ≥30.0 g/day for men, or missing), physical activity (<3.0, 3.0–8.9, 9.0–17.9, 18.0–26.9, ≥27.0 MET-hours/week, or missing), menopausal status and postmenopausal hormone use (premenopause, postmenopause [never, former, or current hormone use], or missing, for women), oral contraceptive use (yes, no, or missing, for NHSII), multivitamin use (yes/no), BMI (<23, 23–24.9, 25–29.9, 30–34.9, ≥35 kg/m2, or missing), and total energy intake (kcal/day), and the modified Alternate Healthy Eating Index score (quintiles).
Results from each cohort were pooled using fixed-effects model.
Abbreviations: BMI, body mass index; HPFS, Health Professionals Follow-Up Study; HR, hazard ratio; MET, metabolic equivalents of task; NHS, Nurses’ Health Study.