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. 2018 Jan 9;26(4):417–423. doi: 10.4062/biomolther.2017.167

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Copyright ©2018, The Korean Society of Applied Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Recombinant IL-1ra reduced chemical irritation-induced IL-1α and IL-1β expression. Western blot analysis of (A) IL-1α and (B) IL-1β in cell lysates and ELISA of (C) IL-1α and (D) IL-1β in culture supernatants at 48 hrs after treatment with HQ, RA, or SLS using the same doses as in Fig. 1. Data in the graph represents mean ± SD of relative values compared to solvent-treated control from 3 independent experiments (^*p<0.05 vs. corresponding chemical concentration without rhIL-1ra treatment).