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. Author manuscript; available in PMC: 2018 Dec 21.
Published in final edited form as: J Phys Chem Lett. 2018 Jun 7;9(12):3368–3371. doi: 10.1021/acs.jpclett.8b01586

Figure 3.

Figure 3

Mapping the sites of large intermolecular PREs observed for the SH3 variants originating from paramagnetic labels located at the rim (R231C and R268C), tail (G545C), and base (S43C) of the GroEL cavity. The SH3 domain is shown as a black ribbon with the regions exhibiting significant intermolecular PREs depicted as transparent surfaces. Three of seven subunits forming a single GroEL ring are depicted as a light-gray molecular surface. A cartoon of the intrinsically disordered C-terminal tail (dark gray), extending upward toward the mouth of the cavity, with the paramagnetic label at G545C, is included in the middle panel. Cys–EDTA–Mn2+ is depicted as a stick diagram with Mn2+ shown as a sphere.