Fig 10.
(A) Impact of DOT provided at home, in the community, or in clinic on TB treatment outcomes. (B) Impact of patient education and counseling interventions on TB treatment outcomes. * = significant heterogeneity in the meta-analysis, as determined by I2 statistic. 1 = adherence defined as the proportion of patients that took >75% of prescribed doses in one CS and the proportion of patients attending all appointments in one RCT. Conversion = sputum conversion to negative at the end of two months. N = number of studies included within the meta-analysis. Composite outcome reported by one study defined as combined failure, default, death, or transfer out. CS, cohort study; DOT, directly observed therapy; LTFU, loss to follow-up; RCT, randomized controlled trial; RR, risk ratio; TB, tuberculosis; UO, unfavorable outcome.