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. 2018 Jul 3;13(7):e0198627. doi: 10.1371/journal.pone.0198627

Fig 1. Combined effect of AKBA and ionizing radiation on the survival of glioblastoma cells.

Fig 1

Cells were irradiated with a single dose and then exposed for 72 hrs to different concentrations of AKBA. The survival was evaluated by XTT colorimetric assay. The graph represents the average survival of treated cells relative to the survival of untreated control cells. The data are mean ± SE values from three individual experiments, each performed in triplicates. Statistical significance was determined by one way ANOVA test (*P < 0.05; **P < 0.01; ***P < 0.001). Normalized isobolograms indicated the mode of interaction between AKBA and ionizing radiation. Combination index for each variant of the combined treatment was calculated using Calcusyn software. The line is the line of additivity: interactions below the line are synergistic while interactions above the line are sub-additive.