Fig 8. Over-expression of miR-140-3p inhibits the mutant v140-t but not wt virus.

A and C: Confluent MARC-145 cells were transfected with the indicated miR-140-3p mimics, inhibitors, or NC. After 24 h, cells were infected with v140-t or v7USC (MOI = 0.05). The supernatants were collected at 36 h to determine viral titers. Virus titers were expressed as the lg TCID₅₀/ml. B and D: qRT-PCR analysis of viral ORF7 RNA levels in MARC-145 cells transfected with miR-140-3p mimics, inhibitors, or NC, followed by v140-t or v7USC infection. The data were normalized to GAPDH expression.