Figure 2.

Typical findings of oligodendroglioma‐like cells and neuropil‐like islands in 19q‐loss anaplastic astrocytomas. A, H&E staining of case 4 (scale bar, 20 μm). Uniformly round‐shaped nuclear and perinuclear halos were observed. B, Representative region of a neuropil‐like island (case 7). H&E staining and immunostaining for class III beta‐tubulin (TUJ1), synaptophysin (Syp), neuronal nuclear antigen (NeuN), oligodendrocyte transcription factor (Olig2), and glial fibrillary acidic protein (GFAP) (scale bar, 50 μm) are shown. Cells in the neuropil‐like island were positive for TUJ1, Syp, NeuN, and Olig2, but negative for GFAP