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. Author manuscript; available in PMC: 2018 Jul 3.
Published in final edited form as: Nat Rev Nephrol. 2017 Dec 13;14(1):8–10. doi: 10.1038/nrneph.2017.170

Figure 1.

Figure 1

Framework for platform adaptive clinical trial for prevention of perioperative AKI. The risk stratification occurs in preoperative period using real time intelligent engine processing clinical data from electronic health records and medical devices. Patients are subsequently and sequentially adaptively randomized to multiple arms. The first sequence involves intraoperative interventions aimed to prevent immediate postoperative renal stress (determined using real time analytics and biomarkers). Based on renal stress patients are adaptively randomized in the next sequence to intervention aimed to prevent AKI and renal recovery.